CASE STUDY Essay Example | Topics and Well Written Essays - 1500 words - 4

CASE STUDY - strain ExampleOn the other hand, fibrates function by moderately starting timeering the levels of LDL while change magnitude those of high density lipoproteins (HDL) in the plasma, and argon recommended for the treatment of hypoalphalipoproteinemia (Staels et al., 1998). This study highlights the steps undertaken in address assignment and validation to optimize the efficacy and recourse of new drugs. This is exemplified by the effect of statin on low density lipoproteins cholesterol levels in dogs.During drug development process, target identification and validation is important as determines the uprise to be use. It is also important so as to identify any issues about reliability, safety and ethics. In this case, target is a broad term referring to biological objects such as proteins, genes and RNA (Hughes et al., 2011). Methods for target identification includeVarious techniques have been employed in target validation which range from in vitro tools such as cult ured cells and yeast to the use of whole animal models such as invertebrates (Drosophila and Caenorhabditis elegans), fish, zebra, rats, mice, hierarch and dogs. Modeling of the wanted target in disease patients has also been applied (Hughes et al., 2011). While each approach is valid in its own right, multi-validation approaches that significantly increase confidence levels in the observed outcome are preferred (Hughes et al., 2011).A total of six cohorts of dogs three statin treated and three placebo treated were used in the study. Each cohort comprised of five dogs. The dogs were fed on chow diet for 21 age after the treatment was introduced. The dogs were administered with either statin (10 mg/kg, 20mg/kg or 30mg/kg rosuvastatin) or fair to middling volume of placebo (0.5 ml of 10% 2-hydroxypropyl--cyclodextrin in autoclaved water) treatment. The serum LDL cholesterol levels were monitored once a hebdomad for six weeks. Blood samples (0.5 ml) were collected from the retro-orb ital plexus